SrasV1, Main, Exploration, bibRecord, 001922

Identification of immunogenic determinants of the spike protein of SARS-like coronavirus.

Identifieur interne : 001922 ( Main/Exploration ); précédent : 001921; suivant : 001923

Identification of immunogenic determinants of the spike protein of SARS-like coronavirus.

Auteurs : Peng Zhou [République populaire de Chine] ; Zhenggang Han ; Lin-Fa Wang ; Zhengli Shi

Source :

Virologica Sinica [ 1995-820X ] ; 2013.

RBID : pubmed:23575730

Descripteurs français

KwdFr :
- Adenoviridae (génétique), Humains, Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), Protéines de l'enveloppe virale (métabolisme), Vaccins antiviraux (immunologie), Virus du SRAS (génétique), Virus du SRAS (immunologie), Virus du SRAS (métabolisme), Épidémiologie moléculaire.
MESH :
- génétique : Adenoviridae, Protéines de l'enveloppe virale, Virus du SRAS.
- immunologie : Protéines de l'enveloppe virale, Vaccins antiviraux, Virus du SRAS.
- métabolisme : Protéines de l'enveloppe virale, Virus du SRAS.
- Humains, Épidémiologie moléculaire.

English descriptors

KwdEn :
- Adenoviridae (genetics), Humans, Molecular Epidemiology, SARS Virus (genetics), SARS Virus (immunology), SARS Virus (metabolism), Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology), Viral Envelope Proteins (metabolism), Viral Vaccines (immunology).
MESH :
- chemical , genetics : Viral Envelope Proteins.
- genetics : Adenoviridae, SARS Virus.
- immunology : SARS Virus, Viral Envelope Proteins, Viral Vaccines.
- metabolism : SARS Virus, Viral Envelope Proteins.
- Humans, Molecular Epidemiology.

Abstract

Bat SARS-like coronavirus (SL-CoV) has a genome organization almost identical to that of SARS-CoV, but the N-terminus of the Spike (S) proteins, which interacts with host receptor and is a major target of neutralizing antibodies against CoVs, of the two viruses has only 63-64% sequence identity. Although there have been reports studying the overall immunogenicity of SSL, knowledge on the precise location of immunodominant determinants for SSL is still lacking. In this study, using a series of truncated expressed SSL fragments and SSL specific mouse sera, we identified two immunogenic determinants for SSL. Importantly, one of the two regions seems to be located in a region not shared by known immunogenic determinants of the SSARS. This finding will be of potential use in future monitoring of SL-CoV infection in bats and spillover animals and in development of more effective vaccine to cover broad protection against this new group of coronaviruses.

DOI: 10.1007/s12250-013-3292-y
PubMed: 23575730

Affiliations:

République populaire de Chine

Le document en format XML

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<term>SARS Virus (immunology)</term>
<term>SARS Virus (metabolism)</term>
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<term>Viral Envelope Proteins (immunology)</term>
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<term>Virus du SRAS (immunologie)</term>
<term>Virus du SRAS (métabolisme)</term>
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<front><div type="abstract" xml:lang="en">Bat SARS-like coronavirus (SL-CoV) has a genome organization almost identical to that of SARS-CoV, but the N-terminus of the Spike (S) proteins, which interacts with host receptor and is a major target of neutralizing antibodies against CoVs, of the two viruses has only 63-64% sequence identity. Although there have been reports studying the overall immunogenicity of SSL, knowledge on the precise location of immunodominant determinants for SSL is still lacking. In this study, using a series of truncated expressed SSL fragments and SSL specific mouse sera, we identified two immunogenic determinants for SSL. Importantly, one of the two regions seems to be located in a region not shared by known immunogenic determinants of the SSARS. This finding will be of potential use in future monitoring of SL-CoV infection in bats and spillover animals and in development of more effective vaccine to cover broad protection against this new group of coronaviruses.</div>
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Serveur d'exploration SRAS

Identification of immunogenic determinants of the spike protein of SARS-like coronavirus.

Identification of immunogenic determinants of the spike protein of SARS-like coronavirus.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
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